In this annual review from the Cato Institute, leading legal scholars analyze the 2021-2022 Supreme Court term, specifically the most important and far-reaching cases of the year, plus cases coming up. Now in its 21st edition, the Review is the first scholarly journal to appear after the term's end and the only one grounded in the nation's first principles, liberty, and limited government. Topics in the 2021-2022 edition include: vaccine mandates (National Federation of Independent Business v. OSHA and Biden v. Missouri), guns (New York State Rifle Association v. Bruen), drugs (Ruan v. United States), free speech (Austin v. Reagan National Advertising), abortion (Dobbs v. Jackson Women's Health Organization), school choice (Carson v. Makin), state secrets (United States v. Zubaydah and FBI v. Fazaga), and much more.